Alison Howlett
Oct 3, 20161 min
AChR antibodies are autoantibodies produced by our immune system, that mistakenly targets proteins called Acetylcholine receptors, these are located on the skeletal muscle fibres.
Acetylcholine is a chemical substance that transmit messages between our nerve cells, muscle movement starts when a impulse is sent down to our nerve endings, when it stimulates the release of acetylcholine.
AChR antibodies obstructs communication between nerves and skeletal muscles, obstructs muscle contraction and causes rapid muscle fatigue, by preventing activation of the acetylcholine receptors. This then causes development of
Myasthenia Gravis - Chronic Autoimmune Disease, this is also associated with presence of these antibodies and there effects on muscle control.
These antibodies do 3 things:-
Binding -Antibodies attach to acetylcholine receptors on our nerve cells
Blocking - Antibodies may stay on the receptors preventing from binding
Modulating - Antibodies may cross-link the receptors.
If you are having symptoms that may suggest you have MG, such as:-
Drooping Eyelids
Double Vision
Difficult to swallow, chew, drilling or gagging
Weak Neck Muscle
Difficulties walking
Muscle weakness, even with rest
If you already have MG an AChR antibody test will evaluate MG disease activity or/and response to Therapy you are having.
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